

While Reito investigates the secrets surrounding the MK Virus and the mysterious disappearance of his childhood friend Elisa Tachibana, the series also shows the perspective of the other men who have developed immunity to the MK Virus, each with their own circumstances. Much to his surprise, Reito also learns that he is one of five men in Japan who somehow developed immunity to the MK Virus and, as a result, is required to participate in a breeding program by impregnating as many women as possible so that their children can replenish the world's population. Five years later in the year 2045, Reito awakens to discover that, in this period of time, an extremely lethal and contagious virus called the MK (Man Killer) has emerged, which mysteriously affects only males, causing the death of about 99.9% of the world's male population except for approximately one million survivors who were put into cryostasis before being infected. In the year 2040, Reito Mizuhara is a young man who is put into cryostasis while awaiting for a life-saving treatment to be developed in order to cure the rare disease he suffers. An anime television series adaptation by Studio Gokumi and AXsiZ premiered its first episode in October 2021 and resumed from January to March 2022. A virtual reality game adaptation developed by DMM Games was released in March 2019.


Two audio dramas were released in May 2017 and August 2021. The series has inspired another manga series, titled World's End Harem: Fantasia and World's End Harem: Britannia Lumiére, respectively. The manga is licensed in North America by Seven Seas Entertainment under its Ghost Ship adult imprint. Its chapters have been collected in fourteen tankōbon volumes as of January 2022. The first part of the manga was serialized in Shueisha's online magazine Shōnen Jump+ from May 2016 to June 2020, while a second part, World's End Harem: After World, started in the same platform in May 2021. World's End Harem ( 終末のハーレム, Shūmatsu no Hāremu) is a Japanese manga series written by LINK and illustrated by Kotaro Shōno.
